From 1976-1979, Danza was a professional boxer who posted a 9-3 record with all wins coming by knockout. He quit fighting when he landed a role on the TV sitcom Taxi.
Danza is probably best-known for his appearances in the TV sitcoms Taxi (1978-1983) and Who's the Boss? (1984-1992).
Danza also starred in the short-lived sitcoms Hudson Street (1995) and The Tony Danza Show (1997, not to be confused with his talk show). He had a role on the TV drama Family Law from 2000 until 2002.
He was nominated for an Emmy Award for a guest-starring 1998 role in the TV series The Practice. His movie debut was in the comedy The Hollywood Knights (1980), which was followed by Going Ape! (1981). He received critical acclaim for his performance in the 1999 Broadway revival of the Eugene O'Neill play The Iceman Cometh.
Danza hosted his own TV talk show, The Tony Danza Show, a nationally syndicated program produced each weekday morning in his hometown of New York (where it aired live). On May 9, 2005, during a go-kart race with NASCAR star Rusty Wallace, who was a guest on the show, Danza's kart flipped after Wallace accidentally bumped him. Neither he nor Wallace was wearing a helmet at the time of the accident. Danza returned to go-kart racing on October 20, 2005, to challenge Indy Car driver Danica Patrick, but he was defeated. His daytime talk show ceased taping in May 2006, with the last live episode airing May 26, 2006.
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