Sara made her Broadway debut as Wahzinak in Paul Simon's The Capeman, starred in The Gershwins' Fascinating Rhythm, for which she received an Outer Critics Circle nomination for Best Actress, and was in Broadway’s A Class Act as Felicia. Off-Broadway she had the honor of performing The Vagina Monologues with Tovah Feldshuh and Suzanne Bertish. Regionally Sara was in The Game as Marquise de Merteuil at The Barrington Stage Company, Anna Deveare Smith's Piano as Alicia at IACD and in starred as Josie in Barrio Babies at the Denver Center.

Sara spent part of her 2004 summer at The Williamstown Theatre Festival and then returned to the role of Hannah on As the World Turns. In the 2004 season finale of NYPD Blue titled "Who's Your Daddy?", she guest starred as Irma Leone (the original air date was May 11). Sara filmed the Untitled Hotel Project for ABC/Warner Brothers for the 2004 season. Her other television credits include Baseball Wives (series regular an HBO pilot), Law & Order SVU (twice), Welcome to New York, Star Patrol (Fox Pilot), Third Watch, Spin City, Talk To Me, As The World Turns (twice).

Her involvement in NY workshops includes: Lennon workshop directed by Don Scardino, Carnival (for Radio City Music Hall), The Laura Nyro Project, and MTC's The Wild Party (Kate). If you've seen You've Got Mail! you've seen Sara as the Zabar's Cashier. She can also be seen in Spiderman (Cop) and in Washington Heights (Belkis) and the film Going Under.

Her concerts include Martinis at the Martin Sara Ramirez with Hollis Resnik at The Ravinia, Bravo! Bernstein (MTW'S 20th ANNIVERSARY GALA CONCERT) at the Hudson Theatre and The Barrington Stage Company Gala where she sang "Wanting Her More" from The Game. She is a Graduate of The Juilliard School's Drama Division.