Natasha Lyonne began her professional career at the age of six when she starred as Opal in the original Pee Wee's Playhouse. After a contract role on As The World Turns, she made her feature film debut as Meryl Streep's niece in the Mike Nichol's film Heartburn.

Other film appearances then led to a lead role in Woody Allen's musical Everyone Says I Love You and her heart-breakingly funny turn as the up-rooted teenager finding her own way in Slums of Beverly Hills for Fox Searchlight.

Successfully moving between challenging independent films and studio box office hits, Lyonne's other credits include But I'm A Cheerleader, Kate & Leopold, Party Monster, Scary Movie 2 and portraying the worldly teenage Vicki in American Pie and its equally successful sequel.