His earlier film credits include Young Guns, Staying Together, Survival Quest (on which he met his future wife, actress Catherine Keener), Longtime Companion, Career Opportunities, Bright Angel, Where the Day Takes You and Point of No Return.
Mulroney then appeared in the features The Thing Called Love, Bad Girls, Angels in the Outfield, There Goes My Baby, How to Make an American Quilt, Living in Oblivion, Copycat, Kansas City, Bastard Out of Carolina, Box of Moonlight, The Trigger Effect and the enormously popular comedy My Best Friend's Wedding, opposite Julia Roberts and Cameron Diaz.
More recently, the actor has been seen in Goodbye Lover, Where the Money Is, Trixie, The Safety of Objects, Lovely & Amazing and, most notably, as Jack Nicholson's mullet-headed, mattress salesman son-in-law in the Oscar-nominated About Schmidt.
Mulroney's TV movie credits include Heart of Justice, Family Pictures, The Last Outlaw and Journeys North. He also had a recurring role on NBC's Friends as Rachel's boss, Gavin Mitchell.
Mulroney appeared in David Gordon Green's feature Undertow, with Jamie Bell and Josh Lucas, and will next be seen in Gary David Goldberg's romantic-comedy Must Love Dogs, with Diane Lane and John Cusack.
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