Christine Taylor starred in the comedy hit, Zoolander. She made notable appearances in the comedies The Wedding Singer (as the promiscuous Holly) and in The Brady Bunch Movie and A Very Brady Sequel. She starred in several independent films, including Desperate But Not Serious, Kiss Toledo Goodbye and Denial. Her other features include The Craft and Overnight Delivery. On television, Taylor starred in the Fox series Party Girl, and she made guest appearances on Seinfeld, Spin City, Friends, Ellen and Murphy Brown.

For the past few years, Taylor has served on the board and has been actively involved with Project A.L. S., an organization that raises funds toward finding a cure and treatments for ALS (amyotrophic lateral sclerosis), a fatal neuromuscular disease.