Christian Kane starred in the independent feature Nantucket, and also starred in the Regency feature film Life or Something Like It opposite Angelina Jolie for director Stephen Herek. He appeared with Ashton Kutcher and Brittany Murphy in Just Married, and also appeared in Summer Catch and Her Minor Thing. Kane was seen opposite Monica Arnold in the MTV film Love Song, and opposite Tom Selleck, in the TNT film Crossfire Trail. Kane also starred for two seasons as Lindsey McDonald on the series Angel. Kane's other film credits include Ron Howard's Ed TV and the independent film Broken Hearts Club, which premiered at the 2000 Sundance Film Festival. Kane also starred on the series Rescue 77.

An accomplished musician, Kane has also been the lead singer of his popular, L.A-based band, Kane.