Flowers, the youngest of six children, was born on June 21, 1981 in Henderson, Nevada (outside Las Vegas) to parents of partial Scottish and Lithuanian ancestry. He has one older brother and three older sisters. Flowers' family lived in Henderson until he was eight and then moved to Nephi, Utah. Brandon lived in Nephi until his junior year in high school, when he moved back to Las Vegas. His mother was a homemaker and his father worked for a grocery store. His parents raised Brandon and the rest of the family as active members of the Church of Jesus Christ of Latter-day Saints and Flowers' remains a devout member of the faith. He has since attributed his fashion sense to his doting sisters.

The person most responsible for Flowers's musical development is his brother Shane, 12 years his senior, who showed him Smiths videos and U2's Rattle and Hum movie. His older brother also introduced him to the Cars, the Beatles, Morrissey, and the Cure. Musically, Flowers identifies as an anglophile and a also as a fan of the bands New Order, the Smiths, and Pet Shop Boys. He credits the latter's song 'Being Boring', especially the lyrics 'I never dreamt that I would get to be/The creature that I always meant to be', as a major life influence. He has stated that "It was really weird because other kids were buying Tool and Nirvana and I was buying the Cars and the Psychedelic Furs. I was pretty alienated as a kid."

Flowers once used a Ouija board and gained a fear of the number 621, which relates to his birthday, June 21. Flowers is convinced he is going to die on that day. He said: "It's just stupid, it is not a way to live. Once I had to fly to Glastonbury on my birthday; that was a real mess."

Flowers, after dropping out of college, was a bellhop for a while at the Gold Coast Hotel and Casino in Las Vegas. In 2001, He was abandoned by the first band that he was in, a synth pop band known as Blush Response, after he declined to move with the rest of them to Los Angeles, California. Shortly thereafter, unexpectedly Flowers attended an Oasis concert, and realizing that he wanted to make the transition from a keyboard band to a true rock band, began searching for a guitarist. He responded to an ad that Dave Keuning had placed in the paper that listed, among other bands, The Cure and Oasis as influences. Keuning later stated that his first impression of Flowers was "I thought he had weird shoes... He had the same shoes Oasis had - Clarks!". After several short-lived bassists and drummers, Flowers and Keuning were joined by bassist Mark Stoermer and drummer Ronnie Vannucci and they became the Killers in August 2002. Vannucci later said that, even with songs like "little dwarf versions of what we have now, Brandon wasn't afraid to just get up there and just do it. You need that when you're trying to get something off the ground. As far as the drive goes, Brandon was never half-assed."

According to the Las Vegas Review-Journal, his parents have always supported his decision to become a rock singer, and were often the only people in the audience at The Killers' first performances in the band's early days. Although primarily a vocalist and keyboardist, Flowers plays bass guitar live in concerts for the song "For Reasons Unknown".

--Wikipedia