Anita Barone's television credits include the series Daddio, The Jeff Foxworthy Show, Life... and Stuff, Ties that Bind, Carol & Company, and "The War at Home". Barone also had a recurring role on Party of Five, and made guest appearances on shows such as Ally McBeal, Friends, Seinfeld, The Larry Sanders Show, Chicago Hope, and Caroline in the City.

Barone's film credits include One Last Ride, The Sex Monster, Dream with the Fishes, Just Friends, I'll Do Anything, and Ricochet.

Theater credits include The Homage that Follows at the Mark Medoff Theater, The Misanthrope at Theatre 40, One Last Ride at the Zephyr Theatre, Sneed the Plow and Barefoot in the Park at Snowmass/Aspen Repertory, and Romeo and Juliet, Nicholas Nickleby, and Macbeth at Hilberry Repertory.