In 1990, Guzmán scored one of the biggest hits of her career, the song Eternamente Bella ("Eternally Beautiful"), which became a number one hit in Mexico and many other Hispanic countries. The song is considered a classic by many Spanish rock fans.
In 1991, she gave birth to her only daughter Frida, named after Frida Kahlo. Later in 2000 she married a German businessman who was soon convicted of a crime in the United States, they divorced shortly after.
In 2002, Guzmán won her first Latin Grammy Award for Best Rock Solo Vocal Album for Soy. Despite being constantly harassed by paparazzi and being in the middle of multiple controversies, Guzmán still remains relatively accessible to her fans, and she signs autographs for them whenever she can. One of these such controversies occurred in April 2003 when Guzmán suffered a miscarriage. She blamed the media for the tragic ending of her pregnancy.
In 2006, she appeared in Open (magazine) on the cover, dressed like a man. That year she released Volverte A Amar, which became one of her biggest hits in Mexico. Her album "Indeleble" turned platinum in less than a month. The album won two awards at the Premios Oye! 2006 (Mexico's most important music awards), including Best Album of the Year and Pop Vocal Female. She was also nominated for two Latin Grammy Awards for Best Rock Vocal Album Indeleble and Best Rock Song for Volverte A Amar.